Genomic context conservation: All the subgroups contain a protein kinase 1 (average of 1.27 copies per genetic context), usually encoded in position +1 and with one transmembrane helix (50.69%, ~100% looking at the MSA). In subgroups ECF62s1 and ECF62s2, the protein kinase is fused to WD repeats (average of 3.18 copies per ECF). WD40 repeats are found mainly in eukaryotes, where they fold into beta propellers that serve as platforms for the reversible binding of protein complexes or the recognition of post-translational modifications (Xu & Min, 2011). In subgroups ECF62s1 (only visible in the MSA), ECF62s2 and ECF62s3, the protein kinase contains a zinc-finger in N-terminal.
Promoter motif conservation: Predicted target promoter motifs are not conserved.
Summary: New and original ECF62 share the same characteristics in terms of conservation of a protein kinase in their genetic neighborhood (Jogler et al., 2012). In this study, we can resolve the domain composition of these kinases, which have WD40 repeats in the largest subgroup and a zinc-finger in ECF62s1, ECF62s2, and ECF62s3.
Number of representative ECFs: 45
Number of non-redundant ECFs: 54
Sequences with C-terminal extension: 1.85%
Sequences with N-terminal extension: 1.85%
Overrepresented class: Planctomycetia [97.78%]
|Structure and function of WD40 domain proteins.||Protein & cell||2011||C. Xu, J. Min||PubMed: 21468892||ECF62|
|Identification of proteins likely to be involved in morphogenesis, cell division, and signal transduction in Planctomycetes by comparative genomics.||Journal of bacteriology||2012||C. Jogler, J. Waldmann, X. Huang, M. Jogler, F. Glöckner, T. Mascher, R. Kolter||PubMed: 23002222||ECF59, ECF46, ECF57, ECF62, ECF61, ECF217, ECF58|