Genomic context conservation: Original ECF59 is associated with protein kinases encoded in position +1 (Jogler et al., 2012). Indeed, we found an average of 0.94 protein kinase domains per ECF in ECF59. These kinases contain six transmembrane helixes in ECF59s1 (ECF59s1: 77.78%) and are fused to a phosphotransferase domain in 33.33% and an ABC-2 family transporter protein in 22.22%. Instead, the protein kinases of ECF59s2 usually contain one transmembrane helix (ECF59s2: 60%) and are fused to tetratricopeptide repeats in 20% of the cases. Interestingly, 40% of the protein encoded in +1 of ECF59s2 are tyrosine kinases, leaving opened if the rest of the protein kinases of ECF59 are also tyrosine kinases.
Promoter motif conservation: Predicted target promoter motifs include a conserved TC in -35.
Number of representative ECFs: 37
Number of non-redundant ECFs: 41
Sequences with C-terminal extension: 0.00%
Sequences with N-terminal extension: 2.44%
Overrepresented class: Planctomycetia [97.30%]
|Identification of proteins likely to be involved in morphogenesis, cell division, and signal transduction in Planctomycetes by comparative genomics.||Journal of bacteriology||2012||C. Jogler, J. Waldmann, X. Huang, M. Jogler, F. Glöckner, T. Mascher, R. Kolter||PubMed: 23002222||ECF59, ECF46, ECF57, ECF62, ECF61, ECF217, ECF58|