Special features: In agreement with original ECF53 (Huang et al., 2015), members of ECF53 contain a C-terminal extension of ~350 aa with a zinc-finger (30%) and an average of about one transmembrane helix. No putative AS factors were identified in the genetic contexts of members of ECF53.
Genomic context conservation: Proteins conserved in the genomic context of members of ECF53 are an aldehyde dehydrogenase, proteins from an ABC transporter and an AsnC-type helix-turn-helix domain.
Summary: ECF53 contains a zinc-binding domain and a transmembrane helix as a C-terminal extension, as in original ECF53 (Huang et al., 2015). It is possible that the C-terminal extension functions as an AS factor.
Number of representative ECFs: 101
Number of non-redundant ECFs: 130
Sequences with C-terminal extension: 100.00%
Sequences with N-terminal extension: 0.00%
Overrepresented order: Streptomycetales [93.07%]
|Environmental Sensing in Actinobacteria: a Comprehensive Survey on the Signaling Capacity of This Phylum.||Journal of bacteriology||2015||X. Huang, D. Pinto, G. Fritz, T. Mascher||PubMed: 25986905||ECF118, ECF218, ECF131, ECF51, ECF123, ECF54, ECF125, ECF132, ECF130, ECF122, ECF52, ECF294, ECF48, ECF56, ECF53, ECF128|