Anti-σ factor: Members of ECF46 contain putative AS factors with one transmembrane helix (92.59%) in position +1. These AS factors typically contain AS domain with homology to FecR AS factor (Pfam: FecR) and an extracytoplasmic region with homology to concanavalin A-like lectin/glucanases (Pfam: Laminin_G_3), a carbohydrate binding domain.
Genomic context conservation: Other proteins conserved in the genomic context include the N-terminal domain of an alpha-L-rhamnosidase (ECF46s4) and a sulfatase fused to a DUF4976 (ECF46s4 and ECF46s3).
Promoter motif conservation: The promoter motifs are not conserved, which might indicate the lack of autoregulation.
Summary: All in all, ECF46 is regulated by one-TM helix-containing FecR-like AS factors that might be sensing carbohydrates in the periplasm of gram-negative organisms.
Number of representative ECFs: 44
Number of non-redundant ECFs: 61
Sequences with C-terminal extension: 0.00%
Sequences with N-terminal extension: 6.56%
Overrepresented phylum: Planctomycetes [50.00%]
|Identification of proteins likely to be involved in morphogenesis, cell division, and signal transduction in Planctomycetes by comparative genomics.||Journal of bacteriology||2012||C. Jogler, J. Waldmann, X. Huang, M. Jogler, F. Glöckner, T. Mascher, R. Kolter||PubMed: 23002222||ECF59, ECF46, ECF57, ECF62, ECF61, ECF217, ECF58|