ECF295 ECF proteins

General description: Members of ECF295 are homologous to sequences of original ECF56 (100%) and are present in Firmicutes (78.57%) and Actinobacteria (21.43%). Members of ECF295 contain a C-terminal extension with homology to SnoaL-like domain (Pfam: snoaL_2) in ECF295s1 and ECF295s2, or to nuclear transport factor 2 (NTF2) domain (Pfam: NFT2) in ECF295s3. An MSA of the ECFs from ECF295 revealed that all the C-terminal extension are homologous to each other.

Genomic context conservation: Members of ECF295 contain an activator of Hsp90 ATPase homolog 1 in position +1 (0.71 copies per ECF). Hsp90 is a chaperone required for proper folding of proteins. Other than this protein and a tetratricopeptide repeat, the genetic context is not conserved.

Promoter motif conservation: Predicted target promoter motifs are not conserved.

Summary: Members of ECF295 might be regulated by their SnoaL-like C-terminal extension, and they could be controlling the activity of Hsp90. Members of ECF295 could be involved in stress response.


Basic information

Number of representative ECFs: 63

Number of non-redundant ECFs: 64

Sequences with C-terminal extension: 100.00%

Sequences with N-terminal extension: 0.00%

Overrepresented phylum: Firmicutes [88.89%]



Sample Neighborhood

Protein WP_047013687.1 of Assembly GCF_000802655.2 (Paenibacillus sp. IHB B 3415)


Promoter Motif



Figures

Protein sequence length distribution

Gene neighbourhood conservation analysis


Overall Pfam domain distribution: Cumulative frequency of Pfam domains across the genetic neighborhoods. Frequency is expressed as number of Pfam domains per ECF sigma factor. Only domains present in more than 75% of the neighborhoods are shown. Genetic neighborhoods contain the proteins encoded in ±10 from the ECF coding sequence. Only the non-overlapping, highest scoring domains are considered positive. If a protein contains several copies of a domain, only one instance is further considered. In order to avoid sequence bias, only proteins from assemblies defined as "representative" or "reference" by NCBI are included (see https://www.ncbi.nlm.nih.gov/assembly/help/).
Pfam domain distribution per position: Frequency of Pfam domain architectures in the proteins encoded in ±10 (x-axis) from the ECF coding sequences. Frequency is expressed as number of times a certain domain architecture appears per ECF sigma factor. Only the highest scoring domains with no position overlap are considered in the domain architectures. Note that the order of the Pfam domains in domain architectures may differ from their name. When a protein contains several copies of a domain, only one instance is further considered. Only domain architectures present in more than 20% of the proteins encoded in any position are shown. In order to avoid sequence bias, only proteins from assemblies defined as "representative" or "reference" by NCBI are included (see https://www.ncbi.nlm.nih.gov/assembly/help/).

Related publications

No publications connected to this ECF group
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