General description: Members of ECF295 are homologous to sequences of original ECF56 (100%) and are present in Firmicutes (78.57%) and Actinobacteria (21.43%). Members of ECF295 contain a C-terminal extension with homology to SnoaL-like domain (Pfam: snoaL_2) in ECF295s1 and ECF295s2, or to nuclear transport factor 2 (NTF2) domain (Pfam: NFT2) in ECF295s3. An MSA of the ECFs from ECF295 revealed that all the C-terminal extension are homologous to each other.
Genomic context conservation: Members of ECF295 contain an activator of Hsp90 ATPase homolog 1 in position +1 (0.71 copies per ECF). Hsp90 is a chaperone required for proper folding of proteins. Other than this protein and a tetratricopeptide repeat, the genetic context is not conserved.
Promoter motif conservation: Predicted target promoter motifs are not conserved.
Number of representative ECFs: 63
Number of non-redundant ECFs: 64
Sequences with C-terminal extension: 100.00%
Sequences with N-terminal extension: 0.00%
Overrepresented phylum: Firmicutes [88.89%]