General description: Members of ECF242 do not have homology to any original group. The topology of the tree follows the taxonomy of its members. ECF242 contain proteins from Proteobacteria (44.19%) (Gammaproteobacteria from genus Alteromonas (ECF242s7), Alphaproteobacteria (ECF242s3 and ECF242s4) and Epsilonproteobacteria (ECF242s5 and ECF242s6)), and Spirochaetes from genus Leptospira (55.81%) (ECF242s1 and ECF242s2).
Anti-σ factor: All the subgroups contain a FecR-like AS factor in position +1, in some cases fused to a DUF4974 and DUF4880, as in other FecR-like AS factors. These AS factors contain one transmembrane helix (100%).
Genomic context conservation Subgroups from Proteobacteria encode at least one TonB-dependent receptor (two in ECF242s7), usually in +2, while this receptor does not appear in subgroups from Spirochaetes (ECF242s1 and ECF242s2). Other proteins conserved in the context of ECF242s1 are a thiolase, a rhodanase (in charge of detoxifying cyanide), a metalloenzyme, an ABC transporter and a DoxX protein (+2) suggesting that ECF242 might be in charge of oxidative stress response at least in ECF242s1, which explains the lack of TonB-dependent receptor.
Promoter motif conservation: Predicted target promoter motifs are not conserved, indicating lack of autoregulation of ECF242.
Summary: ECF242 is a new FecI-like group from which members of ECF242s1 might be in charge of detoxification of harmful compounds rather than functioning in metal uptake. As other FecI-like ECFs (Staroń et al., 2009), members of ECF242 do not seem autoregulated since the predicted target promoter motifs are not conserved.
Number of representative ECFs: 100
Number of non-redundant ECFs: 147
Sequences with C-terminal extension: 0.00%
Sequences with N-terminal extension: 1.36%
Overrepresented phylum: Proteobacteria [58.00%]
|The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) sigma factor protein family.||Molecular microbiology||2009||A. Staroń, H. Sofia, S. Dietrich, L. Ulrich, H. Liesegang, T. Mascher||PubMed: 19737356||ECF103, ECF21, ECF123, ECF51, ECF39, ECF281, ECF102, ECF130, ECF122, ECF291, ECF15, ECF242, ECF22, ECF285, ECF106, ECF27, ECF31, ECF240, ECF114, ECF16, ECF38, ECF41, ECF105, ECF116, ECF111, ECF03, ECF239, ECF42, ECF294, ECF17, ECF11, ECF29, ECF235, ECF293, ECF118, ECF265, ECF30, ECF23, ECF14, ECF249, ECF18, ECF115, ECF290, ECF25, ECF121, ECF02, ECF120, ECF289, ECF28, ECF243, ECF19, ECF43, ECF107, ECF12, ECF32, ECF36, ECF292, ECF286, ECF271, ECF26, ECF40, ECF56, ECF33|