General description: ECF22 has homology to original ECF22 (88.1%). Proteins from this group are present in Bacteroidetes (78.81%), Proteobacteria (18.14%), Verrucomicrobia (1.19%), Planctomycetes (1.02%) and Acidobacteria (0.68%).
Anti-σ factor: Putative AS factors of ECF22 are encoded in +1 and usually contain DUF2207 and four (48.06%) TM helices.
Genomic context conservation: Other proteins conserved in the genetic context of members of ECF22 are an alpha/beta hydrolase (-1 of ECF22s16 and ECF22s4), σ-54 factor (ECF22s8) and two proteins from ABC transporters (-2 and -3 of ECF22s22).
Summary: ECF22 could be regulated by 4-transmembrane helix AS factors located in +1. This expands the knowledge of original ECF22, where putative AS factors were not identified (Staroń et al., 2009). This group seems to be autoregulated since the promoter motifs are conserved.
Number of representative ECFs: 1921
Number of non-redundant ECFs: 1950
Sequences with C-terminal extension: 0.00%
Sequences with N-terminal extension: 0.77%
Overrepresented phylum: Bacteroidetes [79.85%]
|The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) sigma factor protein family.||Molecular microbiology||2009||A. Staroń, H. Sofia, S. Dietrich, L. Ulrich, H. Liesegang, T. Mascher||PubMed: 19737356||ECF103, ECF21, ECF123, ECF51, ECF39, ECF281, ECF102, ECF130, ECF122, ECF291, ECF15, ECF242, ECF22, ECF285, ECF106, ECF27, ECF31, ECF240, ECF114, ECF16, ECF38, ECF41, ECF105, ECF116, ECF111, ECF03, ECF239, ECF42, ECF294, ECF17, ECF11, ECF29, ECF235, ECF293, ECF118, ECF265, ECF30, ECF23, ECF14, ECF249, ECF18, ECF115, ECF290, ECF25, ECF121, ECF02, ECF120, ECF289, ECF28, ECF243, ECF19, ECF43, ECF107, ECF12, ECF32, ECF36, ECF292, ECF286, ECF271, ECF26, ECF40, ECF56, ECF33|
|Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters.||Molecular systems biology||2013||V. Rhodius, T. Segall-Shapiro, B. Sharon, A. Ghodasara, E. Orlova, H. Tabakh, D. Burkhardt, K. Clancy, T. Peterson, C. Gross, C. Voigt||PubMed: 24169405||ECF22, ECF27, ECF03, ECF21, ECF39, ECF25, ECF26, ECF42, ECF38, ECF14, ECF29, ECF33, ECF281, ECF290, ECF291|