General description: ECF22 has homology to original ECF22 (88.1%). Proteins from this group are present in Bacteroidetes (78.81%), Proteobacteria (18.14%), Verrucomicrobia (1.19%), Planctomycetes (1.02%) and Acidobacteria (0.68%).
Anti-σ factor: Putative AS factors of ECF22 are encoded in +1 and usually contain DUF2207 and four (48.06%) TM helices.
Genomic context conservation: Other proteins conserved in the genetic context of members of ECF22 are an alpha/beta hydrolase (-1 of ECF22s16 and ECF22s4), σ-54 factor (ECF22s8) and two proteins from ABC transporters (-2 and -3 of ECF22s22).
Promoter motif conservation: Promoter motifs are conserved and contain TGTGATTTT in -35 and GCGAAT(C/A)AT in -10, in agreement with original ECF22 (Rhodius et al., 2013) and expanding these motifs.
Summary: ECF22 could be regulated by 4-transmembrane helix AS factors located in +1. This expands the knowledge of original ECF22, where putative AS factors were not identified (Staroń et al., 2009). This group seems to be autoregulated since the promoter motifs are conserved.
Number of representative ECFs: 1921
Number of non-redundant ECFs: 1950
Sequences with C-terminal extension: 0.00%
Sequences with N-terminal extension: 0.77%
Overrepresented phylum: Bacteroidetes [79.85%]