Special features: Members of ECF125 are associated with a soluble glyoxalase/bleomycin resistance protein/dioxygenase encoded in +1. This protein could work as an AS factor due to its homology to AS factors in the original classification and to AS factors of group ECF121.
Genomic context conservation: Other than position +1, conserved proteins encoded in the genetic context of members of ECF125 include a TetR represor, a protein from the major facilitator superfamily (ECF125s4), an aminopeptidase I zinc metalloprotease M18 (ECF125s2), an enoyl-CoA hydratase/isomerase (ECF125s2), a CobB/CobQ-like glutamine amidotransferase (ECF125s2), a creatinine amidohydrolase (ECF125s1), an aminotransferase class-III (ECF125s1), a GMC oxidoreductase (ECF125s1), a FMN-dependent dehydrogenase (ECF125s1), a radical SAM with an iron-sulfur cluster (ECF125s1), an amidinotransferase (ECF125s1) and a pyridine nucleotide-disulphide oxidoreductase (ECF125s1).
Promoter motif conservation: The predicted target promoter motifs contain AAAA in -35 and CGTCGGA in -10.
Summary: In conclusion, ECF125 is associated with soluble glyoxalase/bleomycin resistance dioxygenases encoded in position +1 as in original ECF125 (Huang et al., 2015). These proteins could function as AS factors of ECF125.
Number of representative ECFs: 237
Number of non-redundant ECFs: 245
Sequences with C-terminal extension: 0.00%
Sequences with N-terminal extension: 0.41%
Overrepresented class: Actinobacteria [99.58%]
|Environmental Sensing in Actinobacteria: a Comprehensive Survey on the Signaling Capacity of This Phylum.||Journal of bacteriology||2015||X. Huang, D. Pinto, G. Fritz, T. Mascher||PubMed: 25986905||ECF122, ECF56, ECF118, ECF128, ECF51, ECF52, ECF132, ECF53, ECF123, ECF125, ECF54, ECF130, ECF131, ECF218, ECF294, ECF48|