General description: Group ECF123 contains proteins with homology to original ECF123 (97.48%) and are present in Actinobacteria (100%). Proteins from ECF123s1 and ECF123s3 contain a C-terminal extension of 20-30 amino acids with no homology to any Pfam domain.
Special features: Position +1 has homology to AS factors from original ECF123. In this position, 73.33% of the encoded proteins contain one transmembrane helix and are most likely the proteins with homology to AS factors.
Genomic context conservation: Members of ECF123s1 and ECF123s2 encoded one or several transmembrane subunits of the succinate dehydrogenases in their genetic context and a FAD-binding domain, also present in ECF123s6.
Promoter motif conservation: The predicted target promoter motifs of ECF123 is not conserved.
Summary: Most of the members of ECF123 have a transmembrane AS factor in +1. The genomic context conservation extends further in ECF123s1, ECF123s2 with functions related to the electron transport chain, pointing out the potential regulatory role of ECF123 on oxidative stress response.
Number of representative ECFs: 1057
Number of non-redundant ECFs: 994
Sequences with C-terminal extension: 29.18%
Sequences with N-terminal extension: 4.83%
Overrepresented class: Actinobacteria [99.43%]
|The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) sigma factor protein family.||Molecular microbiology||2009||A. Staroń, H. Sofia, S. Dietrich, L. Ulrich, H. Liesegang, T. Mascher||PubMed: 19737356||ECF103, ECF21, ECF123, ECF51, ECF39, ECF281, ECF102, ECF130, ECF122, ECF291, ECF15, ECF242, ECF22, ECF285, ECF106, ECF27, ECF31, ECF240, ECF114, ECF16, ECF38, ECF41, ECF105, ECF116, ECF111, ECF03, ECF239, ECF42, ECF294, ECF17, ECF11, ECF29, ECF235, ECF293, ECF118, ECF265, ECF30, ECF23, ECF14, ECF249, ECF18, ECF115, ECF290, ECF25, ECF121, ECF02, ECF120, ECF289, ECF28, ECF243, ECF19, ECF43, ECF107, ECF12, ECF32, ECF36, ECF292, ECF286, ECF271, ECF26, ECF40, ECF56, ECF33|
|Environmental Sensing in Actinobacteria: a Comprehensive Survey on the Signaling Capacity of This Phylum.||Journal of bacteriology||2015||X. Huang, D. Pinto, G. Fritz, T. Mascher||PubMed: 25986905||ECF122, ECF56, ECF118, ECF128, ECF51, ECF52, ECF132, ECF53, ECF123, ECF125, ECF54, ECF130, ECF131, ECF218, ECF294, ECF48|