General description: Proteins from ECF111 are homologous to original ECF111 (only ECF111s1 and ECF111s2, 15.25% of the total). ECF111 is rich in proteins from underrepresented organisms since it is present in Cyanobacteria (68.75%) (ECF111s1, ECF111s2 and ECF111s4), Thermotogae (14.06%) (ECF111s3), Proteobacteria (10.94%) (ECF111s5), Acidobacteria (4.69%) (ECF111s6) and Fibrobacteres (1.56%) (ECF111s8).
Special features: Proteins from ECF111 might be regulated by a putative AS factor encoded in position +1 with one TM helix (64.91%). Position +2 contains an LTXXQ motif in ECF111s2 and heavy-metal resistance proteins in other subgroups. LTXXQ motif appears in periplasmic proteins that participate in response to stress, and it is also present in ECF03 (Danese & Silhavy, 1998).
Genomic context conservation: The conservation of the genetic context does not go beyond these proteins.
Promoter motif conservation: Predicted target promoter motifs are conserved and contain TTGAACCT in -35 and GTCTAAA in -10, indicating a possible autoregulatory role of ECFs from ECF111.
Summary: AS factors located in +1 might regulate members of ECF111. It is likely that ECF111 is involved in cell envelope stress and/or heavy-metal resistance since the protein in position +1 is typically a heavy-metal resistance protein, and the AS factors contain one transmembrane helix.
Number of representative ECFs: 151
Number of non-redundant ECFs: 177
Sequences with C-terminal extension: 0.00%
Sequences with N-terminal extension: 0.56%
Overrepresented phylum: Cyanobacteria [54.30%]
|CpxP, a stress-combative member of the Cpx regulon.||Journal of bacteriology||1998||P. Danese, T. Silhavy||PubMed: 9473036||ECF03, ECF111|
|The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) sigma factor protein family.||Molecular microbiology||2009||A. Staroń, H. Sofia, S. Dietrich, L. Ulrich, H. Liesegang, T. Mascher||PubMed: 19737356||ECF103, ECF21, ECF123, ECF51, ECF39, ECF281, ECF102, ECF130, ECF122, ECF291, ECF15, ECF242, ECF22, ECF285, ECF106, ECF27, ECF31, ECF240, ECF114, ECF16, ECF38, ECF41, ECF105, ECF116, ECF111, ECF03, ECF239, ECF42, ECF294, ECF17, ECF11, ECF29, ECF235, ECF293, ECF118, ECF265, ECF30, ECF23, ECF14, ECF249, ECF18, ECF115, ECF290, ECF25, ECF121, ECF02, ECF120, ECF289, ECF28, ECF243, ECF19, ECF43, ECF107, ECF12, ECF32, ECF36, ECF292, ECF286, ECF271, ECF26, ECF40, ECF56, ECF33|