ECF proteins

General description: ECF107 is composed by a single subgroup with homology to original ECF107 (98.96%) and present in Firmicutes (100%) from genus Bacillus in organisms such as B. cereus, B. anthracis and B. thuringiensis.

Genetic context conservation: Only five proteins from representative/reference genomes are part of ECF107, making difficult the extraction of meaningful conclusions. These proteins contain a DUF4199 in +2, a DUF5065 in +3, a peptidase family M28 in +4, a tRNA synthetases class I (R) with a DALR anticodon binding domain and an arginyl tRNA synthetase N-terminal domain in -1, a DUF1934 in -2, a LD-carboxypeptidase in -3, a DUF1093 in -4 and a phosphotransferase system EIIC in -5.

Anti-σ factors: In agreement with original ECF017 (Staroń et al., 2009), we observed that position +1 and +2 of the genetic context of members of ECF107 contain a 2-transmembrane helix and 3-transmembrane helix proteins (100%), respectively. Proteins in +1 and +2 are not homologous in the cytoplasmic region, but they could be both AS factors as previously suggested (Staroń et al., 2009).

Promoter motif conservation: Predicted target promoter motifs are not conserved.

Summary: ECF107 preserves the characteristics of original ECF107, with putative AS factors encoded in +1 and +2 (Staroń et al., 2009).


Basic information

Number of representative ECFs: 32

Number of non-redundant ECFs: 96

Sequences with C-terminal extension: 0.00%

Sequences with N-terminal extension: 2.08%

Overrepresented order: Bacillales [96.88%]

Sample Neighborhood

Protein OJD78533.1 of Assembly GCA_001884215.1 (Bacillus sp. P14-1)

Promoter Motif


Protein sequence length distribution

Gene neighbourhood conservation analysis

Related publications

Title Journal Year Authors PubMed ECF groups
The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) sigma factor protein family. Molecular microbiology 2009 A. StaroĊ„, H. Sofia, S. Dietrich, L. Ulrich, H. Liesegang, T. Mascher PubMed: 19737356 ECF103, ECF21, ECF123, ECF51, ECF39, ECF281, ECF102, ECF130, ECF122, ECF291, ECF15, ECF242, ECF22, ECF285, ECF106, ECF27, ECF31, ECF240, ECF114, ECF16, ECF38, ECF41, ECF105, ECF116, ECF111, ECF03, ECF239, ECF42, ECF294, ECF17, ECF11, ECF29, ECF235, ECF293, ECF118, ECF265, ECF30, ECF23, ECF14, ECF249, ECF18, ECF115, ECF290, ECF25, ECF121, ECF02, ECF120, ECF289, ECF28, ECF243, ECF19, ECF43, ECF107, ECF12, ECF32, ECF36, ECF292, ECF286, ECF271, ECF26, ECF40, ECF56, ECF33
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